The timeliness of the topic at the national and global scale matches by its political, economic, and social relevance. The sustainability of urban areas is assailed by a combination of threats never seen before. At a time when—for the 1st time in history—more than 50% of humans reside in cities, the discussion of these topics is unavoidable. Those looming threats demand multidisciplinary approaches both to understand them better and to provide sensible solutions that mitigate the negative effects while amplifying the potential benefits. This class addresses those dimensions (economic, social, environmental, and political) as well as their interactions; it offers a framework under which the potential or already observed impacts are quantified and analyzed; and it surveys the policies implemented around the world. Although there are no explicit pre-requisites, students must have a cursory understanding of economics and basic quantitative analytics.